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In the Before image (Image 1) the schematic attempts to capture the signaling events at the cell membrane that activate downstream RhoGTPases that modify cell responses such as migration and cell division.


In order to mitigate the downstream complexity, the After image (Image 2) simplifies the cell membrane receptors as two dimentional shapes and defines signaling molecules into uniform shapes. The utilization of iconic images such as the stop sign shape is particularly effective in signifying functional roles.



This project appeared as the cover illustration for the August 2011 Journal of Neurosurery Pediatrics. This illustration accompanied a review article by Faria et al. that reviewed the impact of the epigenetic mechanisms that can become altered during the pathogenesis of pediatric brain tumors. A quick review of this illustration depicts epigenetic control at multiple levels of gene expression.



In the Before image (Image 1) the schematic describes cellular respiration pathways including how signaling proteins modulate pathway activity. This busy figure is huge and is dominated by pathway arrows that are disproportionate in size.


In the After image (Image 2), the figure has been dramatically reduced in size yet still retains all of the information required for this review article. The use of different shaded boxes to highlight the various components of cellular respiration gives the viewer a way to focus on different aspects of the figure in order to understand the complexities.


Wolf et al. Oncotarget 2010. 1(7):552-62